ADVERTISEMENT
CURRENT ISSUE
AUGUST 2016
KINDLE EDITION



SEARCH JOURNAL ARCHIVES


SEARCH PUBMED


MANUSCRIPT SUBMISSIONS


SUBSCRIBE TO SLEEP

CONTINUING MEDICAL EDUCATION


ADVERTISE WITH US


ABOUT SLEEP

ABSTRACT SUPPLEMENTS


ACCEPTED PAPERS
Bookmark and Share         RSS Feed

VOLUME 38, ISSUE 08

GENETIC ANCESTRY IS ASSOCIATED WITH SLEEP DEPTH IN OLDER AFRICAN AMERICANS
African Genetic Ancestry is Associated with Sleep Depth in Older African Americans

http://dx.doi.org/10.5665/sleep.4888

Indrani Halder, PhD1; Karen A. Matthews, PhD2; Daniel J. Buysse, MD2; Patrick J. Strollo, MD1; Victoria Causer, MD1; Steven E. Reis, MD1; Martica H. Hall, PhD2

1Department of Medicine, University of Pittsburgh, Pittsburgh, PA; 2Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA



  Expand  Table of Contents    
Text size:  

Study Objectives:

The mechanisms that underlie differences in sleep characteristics between European Americans (EA) and African Americans (AA) are not fully known. Although social and psychological processes that differ by race are possible mediators, the substantial heritability of sleep characteristics also suggests genetic underpinnings of race differences. We hypothesized that racial differences in sleep phenotypes would show an association with objectively measured individual genetic ancestry in AAs.

Design:

Cross sectional.

Setting:

Community-based study.

Participants:

Seventy AA adults (mean age 59.5 ± 6.7 y; 62% female) and 101 EAs (mean age 60.5 ± 7 y, 39% female).

Measurements and Results:

Multivariate tests were used to compare the Pittsburgh Sleep Quality Index (PSQI) and in-home polysomnographic measures of sleep duration, sleep efficiency, apnea-hypopnea index (AHI), and indices of sleep depth including percent visually scored slow wave sleep (SWS) and delta EEG power of EAs and AAs. Sleep duration, efficiency, and sleep depth differed significantly by race. Individual % African ancestry (%AF) was measured in AA subjects using a panel of 1698 ancestry informative genetic markers and ranged from 10% to 88% (mean 67%). Hierarchical linear regression showed that higher %AF was associated with lower percent SWS in AAs (β (standard error) = −4.6 (1.5); P = 0.002), and explained 11% of the variation in SWS after covariate adjustment. A similar association was observed for delta power. No association was observed for sleep duration and efficiency.

Conclusion:

African genetic ancestry is associated with indices of sleep depth in African Americans. Such an association suggests that part of the racial differences in slow-wave sleep may have genetic underpinnings.

Citation:

Halder I, Matthews KA, Buysse DJ, Strollo PJ, Causer V, Reis SE, Hall MH. African genetic ancestry is associated with sleep depth in older African Americans. SLEEP 2015;38(8):1185–1193.

Expand  Table of Contents
ADVERTISEMENT
Classifieds View SLEEP 2011 Poster Presentations Online