GABAA RECEPTOR SUBUNIT GENE CLUSTER AND ZOLPIDEM-INDUCED SLEEP BEHAVIORS
Association between GABAA Receptor Subunit Gene Cluster and Zolpidem-Induced Complex Sleep Behaviors in Han Chinese
Jui-Hsiu Tsai, MD1; Pinchen Yang, MD2; Hung-Hsun Lin, BSc3; Kuang-hung Cheng, PhD4; Yi-Hsin Yang, PhD5; Ming-Tsang Wu, MD, PhD3; Cheng-Chung Chen, MD, PhD6
1Department of Psychiatry, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 2Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Department of Laboratory Medicine and Department of Teaching – Research Center, Kaohsiung Municipal Hsiao-Kang Hospital and Graduate Institute of Occupational Safety and Health, Kaohsiung Medical University, Kaohsiung, Taiwan; 4Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan; 5Statistical Analysis Laboratory, Department of Clinical Research, Kaohsiung Medical University Hospital and School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; 6Kaohsiung Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan
To investigate and elucidate the role of GABAA receptor subunits, specifically the 2 genetic markers at the GABAA α1 and GABAA α6 receptors, in zolpidem-induced complex sleep behaviors (CSBs).
Genetic association study.
Kaohsiung Medical University-affiliated hospitals, Kaohsiung, Taiwan.
30 zolpidem-induced CSB subjects and 37 controls.
Measurements and Results:
The χ2 test demonstrated an association between the A15G variant at the GABAA α1 receptor subunit gene and zolpidem-induced CSBs (P = 0.007). The adjusted odds ratio of the GABAA α1 receptor subunit genotype for the risk of zolpidem-induced CSBs was approximately 10 (OR = 9.99, 95% CI = 1.82, 74.87; P = 0.013).
The finding reveals that the A15G variant at the GABAA α1 receptor subunit gene confers a high risk of zolpidem-induced CSBs and may be considered in clinical services.
Tsai JH; Yang P; Lin HH; Cheng Kh; Yang YH; Wu MT; Chen CC. Association between GABAA receptor subunit gene cluster and zolpidem-induced complex sleep behaviors in Han Chinese. SLEEP 2013;36(2):197–202.