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VOLUME 35, ISSUE 11

SHORT SLEEP DURATION, GLUCOSE DYSREGULATION AND REGULATION OF APPETITE
Short Sleep Duration, Glucose Dysregulation and Hormonal Regulation of Appetite in Men and Women

http://dx.doi.org/10.5665/sleep.2198

Marie-Pierre St-Onge, PhD1,2; Majella O'Keeffe, PhD1; Amy L. Roberts, MSc1; Arindam RoyChoudhury, PhD3; Blandine Laferrère, MD1,2

1New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY; 2Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY; 3Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY



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Study Objective:

To determine the hormonal effects of reducing sleep duration under controlled feeding conditions.

Design:

Randomized, crossover study.

Setting:

Inpatient.

Participants:

Twenty-seven normal weight, 30- to 45-yr-old men and women habitually sleeping 7-9 hr/night.

Intervention:

Participants were studied under two sleep conditions: short (4 hr in bed) or habitual (9 hr in bed) sleep. A controlled diet was provided for each 4-day study period.

Measurements and Results:

Fasting blood samples were obtained daily and frequent blood samples were obtained throughout day 4. The main outcomes measures included glucose, insulin, leptin, ghrelin, adiponectin, total glucagon-like peptide 1 (GLP-1) and peptide YY3-36 (PYY3-36) concentrations. Body weights were reduced by 2.2 ± 0.4 lb and 1.7 ± 0.4 lb during the habitual and short sleep phases, respectively (both P < 0.0001). There was no effect of sleep duration on glucose, insulin, and leptin profiles (all P > 0.05). Ghrelin and GLP-1 responses differed by sex. Short sleep increased fasting (P = 0.054) and morning (08:00-12:00) (P = 0.042) total ghrelin in men but not women. The reverse was observed for GLP-1: afternoon levels (12:30-19:00) were lower (P = 0.016) after short sleep compared with habitual sleep in women but not men.

Conclusions:

These data suggest that, in the context of negative energy balance, short sleep does not lead to a state of increased insulin resistance, but may predispose to overeating via separate mechanisms in men and women.

Clinical Trial Information:

Trial registration on http://www.clinicaltrials.gov. #NCT00935402.

Citation:

St-Onge MP; O'Keeffe M; Roberts AL; RoyChoudhury A; Laferrère B. Short sleep duration, glucose dysregulation and hormonal regulation of appetite in men and women. SLEEP 2012;35(11):1503-1510.

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