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VOLUME 35, ISSUE 06

COMMENTARY
The Role of GABA in Primary Insomnia

http://dx.doi.org/10.5665/sleep.1854

David T. Plante, MD¹; J. Eric Jensen, PhD²^,³; John W. Winkelman, MD, PhD²^,⁴

¹Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Department of Psychiatry, Harvard Medical School, Boston, MA; ³Brain Imaging Center, McLean Hospital, Belmont, MA; ⁴Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA

VOLUME 35, ISSUE 06

Errata. 725.

Sleep: A Health Imperative. 727-734.
Faith S. Luyster, PhD¹; Patrick J. Strollo, MD²; Phyllis C. Zee, MD, PhD³; James K. Walsh, PhD⁴

“The Times They Are A Changin:” Home Diagnosis of Sleep Apnea Has Arrived. 735-736.
Charles W. Atwood, MD

The Further Rise of Internet Interventions. 737-738.
Lee M. Ritterband, PhD; Frances P. Thorndike, PhD

Searching for Genetic Clues at the Interface of Sleep and Mood. 739-740.
Namni Goel, PhD

The Role of GABA in Primary Insomnia. 741-742.
David T. Plante, MD¹; J. Eric Jensen, PhD²^,³; John W. Winkelman, MD, PhD²^,⁴

Respect for Muscle. 743-744.
Donald L. Bliwise, PhD; David B. Rye, MD, PhD

The Young and the Rest-less. 745-746.
Christine M. Walsh, PhD¹; Gina R. Poe, PhD²

Early Treatment of Obstructive Apnea and Stroke Outcome. 747.
Olga Parra, MD¹^,³; Adrià Arboix, MD, PhD²^,³

Response to the Letter to the Editor from Parra and Arboix. 749.
Dawn M. Bravata, MD¹; H. Klar Yaggi, MD, MPH²

Guidance Needed in Patient-Centered Medical Home Concept for Management of Obstructive Sleep Apnea. 751.
David Kuhlmann, MD

Reply to Letter to the Editor - Guidance Needed in Patient-Centered Medical Home Concept for Management of Obstructive Sleep Apnea by David Kuhlmann, MD. 753.
Patrick J. Strollo, MD¹; M. Safwan Badr, MD²; Michael P. Coppola, MD³; Samuel A. Fleishman, MD⁴; Ofer Jacobowitz, MD, PhD⁵; Clete A. Kushida, MD, PhD, RPSGT⁶

The Clinical Dilema: To Treat or Not to Treat REM Related Obstructive Sleep Apnea?. 755.
Gautam Ganguly, MD

A Multisite Randomized Trial of Portable Sleep Studies and Positive Airway Pressure Autotitration Versus Laboratory-Based Polysomnography for the Diagnosis and Treatment of Obstructive Sleep Apnea: The HomePAP Study. 757-767.
Carol L. Rosen, MD¹; Dennis Auckley, MD²; Ruth Benca, MD³; Nancy Foldvary-Schaefer, DO⁴; Conrad Iber, MD⁵; Vishesh Kapur, MD⁶; Michael Rueschman, MPH⁷; Phyllis Zee, MD⁸; Susan Redline, MD⁹

A Randomized, Placebo-Controlled Trial of Online Cognitive Behavioral Therapy for Chronic Insomnia Disorder Delivered via an Automated Media-Rich Web Application. 769-781.
Colin A. Espie, PhD¹^,²^,⁶; Simon D. Kyle, PhD¹^,²; Chris Williams, MD³; Jason C. Ong, PhD⁴; Neil J. Douglas, MD, DSc⁵; Peter Hames, MA Oxon⁶; June S.L. Brown, PhD⁷

Sleep Is Associated with the Metabolic Syndrome in a Multi-Ethnic Cohort of Midlife Women: The SWAN Sleep Study. 783-790.
Martica H. Hall, PhD¹; Michele L. Okun, PhD¹; MaryFran Sowers, PhD²; Karen A. Matthews, PhD¹; Howard M. Kravitz, DO, MPH³; Kimberly Hardin, MD⁴; Daniel J. Buysse, MD¹; Joyce T. Bromberger, PhD¹; Jane F. Owens, DrPH¹; Irina Karpov, MS¹; Mark H. Sanders, MD¹

Short Sleep as an Environmental Exposure: A Preliminary Study Associating 5-HTTLPR Genotype to Self-Reported Sleep Duration and Depressed Mood in First-Year University Students. 791-796.
Mary A. Carskadon, PhD¹^,²; Katherine M. Sharkey, MD, PhD¹^,³; Valerie S. Knopik, PhD⁴^,¹; John E. McGeary, PhD⁵^,⁴^,¹

Dismantling Multicomponent Behavioral Treatment for Insomnia in Older Adults: A Randomized Controlled Trial. 797-805.
Dana R. Epstein, PhD, RN¹^,⁴; Souraya Sidani, PhD, RN²; Richard R. Bootzin, PhD³; Michael J. Belyea, PhD⁴

Cortical GABA Levels in Primary Insomnia. 807-814.
Peter T. Morgan, MD, PhD¹; Edward F. Pace-Schott, PhD²; Graeme F. Mason, PhD¹^,³; Erica Forselius, BA¹; Madonna Fasula, APRN¹; Gerald W. Valentine, MD¹; Gerard Sanacora, MD, PhD¹

The Longitudinal Course of Insomnia Symptoms: Inequalities by Sex and Occupational Class Among Two Different Age Cohorts Followed for 20 Years in the West of Scotland. 815-823.
Michael J. Green, MA¹; Colin A. Espie, PhD²; Kate Hunt, PhD¹; Michaela Benzeval, PhD¹

Insomnia, Comorbidity, and Risk of Injury Among Insured Americans: Results from the America Insomnia Survey. 825-834.
Ronald C. Kessler, PhD¹; Patricia A. Berglund, MBA²; Catherine Coulouvrat, MD³; Timothy Fitzgerald, PhD⁴; Goeran Hajak, MD⁵; Thomas Roth, PhD⁶; Victoria Shahly, PhD¹; Alicia C. Shillington, PhD⁷; Judith J. Stephenson, SM⁸; James K. Walsh, PhD⁹

Normative EMG Values during REM Sleep for the Diagnosis of REM Sleep Behavior Disorder. 835-847.
Birgit Frauscher, MD¹; Alex Iranzo, MD²; Carles Gaig, MD²; Viola Gschliesser, MD¹; Marc Guaita, MD²; Verena Raffelseder, MD¹; Laura Ehrmann, MD¹; Nuria Sola, MD²; Manel Salamero, PhD³; Eduardo Tolosa, MD²; Werner Poewe, MD¹; Joan Santamaria, MD²; Birgit Högl, MD¹

Repeated Sleep Restriction in Adolescent Rats Altered Sleep Patterns and Impaired Spatial Learning/Memory Ability. 849-859.
Su-Rong Yang, PhD¹^,²; Hui Sun, Candidate Master¹; Zhi-Li Huang, PhD¹^,²; Ming-Hui Yao, PhD¹; Wei-Min Qu, PhD¹^,²

Decoupling of Sleepiness from Sleep Time and Intensity during Chronic Sleep Restriction: Evidence for a Role of the Adenosine System. 861-869.
Youngsoo Kim, PhD; Yunren Bolortuya, MD; Lichao Chen, MD, PhD; Radhika Basheer, PhD; Robert W. McCarley, MD; Robert E. Strecker, PhD

The Effects of a Nighttime Nap on the Error-Monitoring Functions During Extended Wakefulness. 871-878.
Shoichi Asaoka, PhD¹^,²; Kazuhiko Fukuda, PhD³; Timothy I. Murphy, PhD⁴; Takashi Abe, PhD¹^,²; Yuichi Inoue, PhD, MD¹^,²

Telemetric Study of Sleep Architecture and Sleep Homeostasis in the Day-Active Tree Shrew Tupaia belangeri. 879-888.
Alex Coolen¹; Kerstin Hoffmann, DVM²; R. Paulien Barf¹; Eberhard Fuchs, PhD²; Peter Meerlo, PhD¹

Obituary for Gerald W. Vogel, MD. 889.
David Foulkes¹; Allan Rechtschaffen²; Thomas Roth³

Table of Contents

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VOLUME 35, ISSUE 06

Errata. 725.

Sleep: A Health Imperative. 727-734.
Faith S. Luyster, PhD¹; Patrick J. Strollo, MD²; Phyllis C. Zee, MD, PhD³; James K. Walsh, PhD⁴

“The Times They Are A Changin:” Home Diagnosis of Sleep Apnea Has Arrived. 735-736.
Charles W. Atwood, MD

The Further Rise of Internet Interventions. 737-738.
Lee M. Ritterband, PhD; Frances P. Thorndike, PhD

Searching for Genetic Clues at the Interface of Sleep and Mood. 739-740.
Namni Goel, PhD

The Role of GABA in Primary Insomnia. 741-742.
David T. Plante, MD¹; J. Eric Jensen, PhD²^,³; John W. Winkelman, MD, PhD²^,⁴

Respect for Muscle. 743-744.
Donald L. Bliwise, PhD; David B. Rye, MD, PhD

The Young and the Rest-less. 745-746.
Christine M. Walsh, PhD¹; Gina R. Poe, PhD²

Early Treatment of Obstructive Apnea and Stroke Outcome. 747.
Olga Parra, MD¹^,³; Adrià Arboix, MD, PhD²^,³

Response to the Letter to the Editor from Parra and Arboix. 749.
Dawn M. Bravata, MD¹; H. Klar Yaggi, MD, MPH²

Guidance Needed in Patient-Centered Medical Home Concept for Management of Obstructive Sleep Apnea. 751.
David Kuhlmann, MD

The Clinical Dilema: To Treat or Not to Treat REM Related Obstructive Sleep Apnea?. 755.
Gautam Ganguly, MD

Obituary for Gerald W. Vogel, MD. 889.
David Foulkes¹; Allan Rechtschaffen²; Thomas Roth³

Table of Contents

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