ADVERTISEMENT
CURRENT ISSUE
DECEMBER 2014
KINDLE EDITION



SEARCH JOURNAL ARCHIVES


SEARCH PUBMED


MANUSCRIPT SUBMISSIONS


SUBSCRIBE TO SLEEP

CONTINUING MEDICAL EDUCATION


ADVERTISE WITH US


ABOUT SLEEP

ABSTRACT SUPPLEMENTS


ACCEPTED PAPERS
Bookmark and Share         RSS Feed

VOLUME 35, ISSUE 01

PROSPECTIVE STUDY OF SLEEP DURATION AND PNEUMONIA RISK IN WOMEN
A Prospective Study of Sleep Duration and Pneumonia Risk in Women

http://dx.doi.org/10.5665/sleep.1594

Sanjay R. Patel, MD, MS1; Atul Malhotra, MD1; Xiang Gao, MD, PhD2; Frank B. Hu, MD, PhD2; Mark I. Neuman, MD, MPH3; Wafaie W. Fawzi, MD, DrPH2,4

1Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA; 2Department of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA; 3Department of Epidemiology and Nutrition, Division of Emergency Medicine, Children's Hospital, Boston, MA; 4Department of Global Health and Population, Harvard School of Public Health, Boston, MA



  Expand  Table of Contents    
Text size:  

Study Objective:

Experimental data suggest sleep deprivation may impair host immunity. We sought to assess the effect of poor sleep on pneumonia risk.

Design:

Prospective, observational cohort study.

Participants:

56,953 female nurses (ages 37 to 57 years old) participating in the Nurses' Health Study II cohort free of cancer, cardiovascular disease, diabetes, and asthma with no prior history of pneumonia.

Measurements and Results:

At baseline, participants reported their average sleep duration and whether this quantity was adequate for them. Questionnaires ascertaining a new pneumonia diagnosis were mailed every 2 years. Cases required physician diagnosis and chest radiograph confirmation. Cox proportional hazards models were used to assess the relative risk for incident pneumonia over 4 years. Over 217,500 person-years, 977 cases of pneumonia were identified. Relative to 8-h sleepers, both short and long sleep durations were associated with elevated pneumonia risk. The age-adjusted relative risk for pneumonia was 1.70 (95% CI 1.30-2.23) in those sleeping ≤ 5 h and 1.49 (95% CI 1.12-1.98) in those sleeping ≥ 9 h. After adjusting for potential confounders, the relative risks were 1.39 (95% CI: 1.06-1.82) in those sleeping ≤ 5 h and 1.38 (95% CI 1.04-1.84) in those sleeping ≥ 9 h. Perceived inadequate sleep was also associated with pneumonia with a relative risk of 1.50 (95% CI 1.29-1.74) in multivariate models.

Conclusions:

Both reduced and prolonged habitual sleep durations are associated with increased risk of pneumonia. Further research is needed to understand how sleep habits can influence immunity.

Citation:

Patel SR; Malhotra A; Gao X; Hu FB; Neuman MI; Fawzi WW. A prospective study of sleep duration and pneumonia risk in women. SLEEP 2012;35(1):97-101.

Expand  Table of Contents
ADVERTISEMENT
Classifieds View SLEEP 2011 Poster Presentations Online