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VOLUME 35, ISSUE 01

SLEEP, GLUCOSE, AND DAYTIME FUNCTION IN YOUTH WITH TYPE 1 DIABETES
Sleep, Glucose, and Daytime Functioning in Youth with Type 1 Diabetes

http://dx.doi.org/10.5665/sleep.1590

Michelle M. Perfect, PhD1; Priti G. Patel, MD2; Roxanne E. Scott, MA1; Mark D. Wheeler, MD2; Chetanbabu Patel, MD2; Kurt Griffin, PhD, MD2; Seth T. Sorensen, MA1; James L. Goodwin, PhD3; Stuart F. Quan, MD3,4

1Department of Disability and Psychoeducational Studies, University of Arizona, Tucson, AZ; 2Department of Pediatrics, Section of Endocrinology, University of Arizona, Tucson, AZ; 3Arizona Respiratory Center, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ; 4Division of Sleep Medicine, Harvard Medical School, Boston, MA



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Study Hypotheses:

1) Youth with evidence of SDB (total apnea-hypopnea index [Total-AHI] ≥ 1.5) would have significantly worse glucose control than those without SDB; 2) Elevated self-reported sleepiness in youth with T1DM would be related to compromised psychosocial functioning; and 3) Youth with T1DM would have significantly less slow wave sleep (SWS) than controls.

Design:

The study utilized home-based polysomnography, actigraphy, and questionnaires to assess sleep, and continuous glucose monitors and hemoglobin A1C (HbA1C) values to assess glucose control in youth with T1DM. We compared sleep of youth with T1DM to sleep of a matched control sample.

Setting:

Diabetic participants were recruited in a pediatric endocrinology clinic.

Participants:

Participants were youth (10 through 16 years) with T1DM. Controls, matched for sex, age, and BMI percentile, were from the Tucson Children's Assessment of Sleep Apnea study.

Results:

Participants with a Total-AHI ≥ 1.5 had higher glucose levels. Sleepiness and/or poor sleep habits correlated with reduced quality of life, depressed mood, lower grades, and lower state standardized reading scores. Diabetic youth spent more time (%) in stage N2 and less time in stage N3. Findings related to sleep architecture included associations between reduced SWS and higher HbA1C, worse quality of life, and sleepiness. More time (%) spent in stage N2 related to higher glucose levels/hyperglycemia, behavioral difficulties, reduced quality of life, lower grades, depression, sleep-wake behavior problems, poor sleep quality, sleepiness, and lower state standardized math scores.

Conclusions:

Sleep should be routinely assessed as part of diabetes management in youth with T1DM.

Citation:

Perfect MM; Patel PG; Scott RE; Wheeler MD; Patel C; Griffin K; Sorensen ST; Goodwin JL; Quan SF. Sleep, glucose, and daytime functioning in youth with type 1 diabetes. SLEEP 2012;35(1):81-88.

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