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VOLUME 34, ISSUE 11

COMMENTARY AND PERSPECTIVE
Genetic Underpinnings of Obstructive Sleep Apnea: Are We Making Progress?

http://dx.doi.org/10.5665/sleep.1366

Patrick Sleiman, PhD¹^,²; Hakon Hakonarson, MD, PhD¹^,²^,³

¹The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA; ²Division of Genetics, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA; ³Division of Pulmonary Medicine, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA

VOLUME 34, ISSUE 11

Genetic Underpinnings of Obstructive Sleep Apnea: Are We Making Progress?. 1449-1452.
Patrick Sleiman, PhD¹^,²; Hakon Hakonarson, MD, PhD¹^,²^,³

Searching for the Missing Heritability. 1453-1454.
Nathaniel F. Watson, MD, MSc

Back to the Future or Forward to the Past?. 1455-1456.
Samuel T. Kuna, MD

Are Short Bad Sleep Nights a Hindrance to a Healthy Heart?. 1457-1458.
Francesco P. Cappuccio, FRCP, FFPH; Michelle A. Miller, PhD, FFPH

Toward a Multi-Level Approach to CPAP Adherence. 1459-1460.
Alec B. Platt, MD, MSCE¹^,²; Nirav P. Patel, MD, MPH¹^,²

A Review of Genetic Association Studies of Obstructive Sleep Apnea: Field Synopsis and Meta-Analysis. 1461-1468.
Vasileia Varvarigou, MD¹^,²; Issa J. Dahabreh, MD³; Atul Malhotra, MD⁴; Stefanos N. Kales, MD, MPH¹^,²

Identification of Causal Genes, Networks, and Transcriptional Regulators of REM Sleep and Wake. 1469-1477.
Joshua Millstein, PhD¹; Christopher J. Winrow, PhD²; Andrew Kasarskis, PhD³; Joseph R. Owens, BE⁴; Lili Zhou, BS⁴; Keith C. Summa, BS⁴; Karrie Fitzpatrick, BS⁴; Bin Zhang, PhD¹; Martha H. Vitaterna, PhD⁴; Eric E. Schadt, PhD³; John J. Renger, PhD²; Fred W. Turek, PhD⁴

Treating Obstructive Sleep Apnea with Hypoglossal Nerve Stimulation. 1479-1486.
Peter R. Eastwood, PhD¹^,²; Maree Barnes, MBBS³; Jennifer H. Walsh, PhD¹^,²; Kathleen J. Maddison, BSc¹^,²; Geoffrey Hee, MBBS; Alan R. Schwartz, MD⁵; Philip L. Smith, MD⁵; Atul Malhotra, MD⁶; R. Douglas McEvoy, MBBS⁷^,¹¹^,¹⁵; John R. Wheatley, MBBS, PhD⁸; Fergal J. O'Donoghue, MBBS, PhD³^,⁴; Peter D. Rochford, BAppSc, GradDip (Bio Instr)³^,⁹; Tom Churchward, RPSGT³; Matthew C. Campbell, MBBS³; Carsten E. Palme, MBBS¹⁰; Sam Robinson, MBBS¹¹; George S. Goding, MD¹²; Danny J. Eckert, PhD¹³; Amy S. Jordan, PhD⁴; Peter G. Catcheside, PhD⁷^,¹¹^,¹⁵; Louise Tyler, RN, RPSGT⁸^,¹⁴; Nick A. Antic, MBBS, PhD⁷^,¹¹^,¹⁵; Christopher J. Worsnop, MBBS, PhD³^,⁴; Eric J. Kezirian, MD, MPH¹⁶; David R. Hillman, MBBS¹

Sleep Duration and Sleep Quality in Relation to 12-Year Cardiovascular Disease Incidence: The MORGEN Study. 1487-1492.
Marieke P. Hoevenaar-Blom, MSc¹^,²; Annemieke M.W. Spijkerman, PhD¹; Daan Kromhout, MPH, PhD²; Julia F. van den Berg, PhD³; W.M. Monique Verschuren, PhD¹

Poor Sleep Quality is Associated with Preterm Birth. 1493-1498.
Michele L. Okun, PhD¹; Christine Dunkel Schetter, PhD²; Laura M. Glynn, PhD³^,⁴

Poor Sleep Quality Predicts Deficient Emotion Information Processing over Time in Early Adolescence. 1499-1508.
Nirit Soffer-Dudek, PhD¹; Avi Sadeh, DSc¹; Ronald E. Dahl, MD²; Shiran Rosenblat-Stein, MA¹

The Childhood Adenotonsillectomy Trial (CHAT): Rationale, Design, and Challenges of a Randomized Controlled Trial Evaluating a Standard Surgical Procedure in a Pediatric Population. 1509-1517.
Susan Redline, MD, MPH¹; Raouf Amin, MD²; Dean Beebe, PhD²; Ronald D. Chervin, MD, MS³; Susan L. Garetz, MD⁴; Bruno Giordani, PhD⁵; Carole L. Marcus, MBBCh⁶; Renee H. Moore, PhD⁷; Carol L. Rosen, MD⁸; Raanan Arens, MD⁹; David Gozal, MD¹⁰; Eliot S. Katz, MD¹¹; Ronald B. Mitchell, MD, PhD¹²; Hiren Muzumdar, MD⁹; H.G. Taylor, PhD⁸; Nina Thomas, PhD¹³; Susan Ellenberg, PhD⁷

Loneliness Is Associated with Sleep Fragmentation in a Communal Society. 1519-1526.
Lianne M. Kurina, PhD¹; Kristen L. Knutson, PhD²; Louise C. Hawkley, PhD³; John T. Cacioppo, PhD³; Diane S. Lauderdale, PhD¹; Carole Ober, PhD⁴

State-Dependent Changes in Cortical Gain Control as Measured by Auditory Evoked Responses to Varying Intensity Stimuli. 1527-1537.
Derrick J. Phillips, BS¹; Jennifer L. Schei, PhD²; Peter C. Meighan, PhD¹; David M. Rector, PhD¹

Antagonizing Corticotropin-Releasing Factor in the Central Nucleus of the Amygdala Attenuates Fear-induced Reductions in Sleep but not Freezing. 1539-1549.
Xianling Liu, MD, PhD; Laurie L. Wellman, PhD; Linghui Yang, MS; Marta A. Ambrozewicz, MD, PhD; Xiangdong Tang, MD, PhD; Larry D. Sanford, PhD

Sleep-Stage Dynamics in Patients with Chronic Fatigue Syndrome with or without Fibromyalgia. 1551-1560.
Akifumi Kishi, PhD¹^,²^,³; Benjamin H. Natelson, MD⁴; Fumiharu Togo, PhD⁵; Zbigniew R. Struzik, PhD¹; David M. Rapoport, MD³; Yoshiharu Yamamoto, PhD¹

Evaluation of the Association of Menopausal Status with Delta and Beta EEG Activity during Sleep. 1561-1568.
Ian G. Campbell, PhD¹; Joyce T. Bromberger, PhD²^,³; Daniel J. Buysse, MD³; Martica H. Hall, PhD³; Kimberly A. Hardin, MD⁴; Howard M. Kravitz, DO, MPH⁵; Karen A. Matthews, PhD²^,³; Marianne O'Neill Rasor, MA⁶; Jessica Utts, PhD⁷; Ellen Gold, PhD⁶

Quantification of the Fragmentation of Rest-Activity Patterns in Elderly Individuals Using a State Transition Analysis. 1569-1581.
Andrew S.P. Lim, MD¹; Lei Yu, PhD²; Madalena D. Costa, PhD³^,⁴; Aron S. Buchman, MD²; David A. Bennett, MD²; Sue E. Leurgans, PhD²; Clifford B. Saper, MD, PhD¹

Self-Reported Sleep Duration and Time in Bed as Predictors of Physical Function Decline: Results from the InCHIANTI Study. 1583-1593.
Sari Stenholm, PhD¹; Erkki Kronholm, PhD²; Stefania Bandinelli, MD³; Jack M. Guralnik, MD, PhD⁴; Luigi Ferrucci, MD, PhD⁵

Ethnic Disparities in CPAP Adherence in New Zealand: Effects of Socioeconomic Status, Health Literacy and Self-Efficacy. 1595-1603.
Jessie P. Bakker, PhD; Karyn M. O'Keeffe, BSc (Hons); Alister M. Neill, FRACP, MD; Angela J. Campbell, PhD

Increased Aortic Root Size is Associated with Nocturnal Hypoxia and Diastolic Blood Pressure in Obstructive Sleep Apnea. 1605-1607.
Jean-Philippe Baguet, MD, PhD¹^,²; Caroline Minville, MD³^,⁴; Renaud Tamisier, MD, PhD³^,⁴; Frederic Roche, MD, PhD⁵; Gilles Barone-Rochette, MD¹^,²; Olivier Ormezzano, MD, PhD¹^,²; Patrick Levy, MD, PhD³^,⁴; Jean-Louis Pepin, MD, PhD³^,⁴

Erratum. 1608.
Ronald C. Kessler, PhD

Table of Contents

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VOLUME 34, ISSUE 11

Genetic Underpinnings of Obstructive Sleep Apnea: Are We Making Progress?. 1449-1452.
Patrick Sleiman, PhD¹^,²; Hakon Hakonarson, MD, PhD¹^,²^,³

Searching for the Missing Heritability. 1453-1454.
Nathaniel F. Watson, MD, MSc

Back to the Future or Forward to the Past?. 1455-1456.
Samuel T. Kuna, MD

Are Short Bad Sleep Nights a Hindrance to a Healthy Heart?. 1457-1458.
Francesco P. Cappuccio, FRCP, FFPH; Michelle A. Miller, PhD, FFPH

Toward a Multi-Level Approach to CPAP Adherence. 1459-1460.
Alec B. Platt, MD, MSCE¹^,²; Nirav P. Patel, MD, MPH¹^,²

Poor Sleep Quality is Associated with Preterm Birth. 1493-1498.
Michele L. Okun, PhD¹; Christine Dunkel Schetter, PhD²; Laura M. Glynn, PhD³^,⁴

Erratum. 1608.
Ronald C. Kessler, PhD

Table of Contents

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