SHARED GENETIC BACKGROUND FOR REGULATION OF MOOD AND SLEEP
Shared Genetic Background for Regulation of Mood and Sleep: Association of GRIA3 with Sleep Duration in Healthy Finnish Women
Siddheshwar Utge, MSc1,2,3,4; Erkki Kronholm, PhD5; Timo Partonen, MD, PhD6; Pia Soronen, MSc1,3,4; Hanna M. Ollila, MSc1,2,4; Anu Loukola, PhD1; Markus Perola, MD, PhD1; Veikko Salomaa, MD, PhD7; Tarja Porkka-Heiskanen, MD, PhD2; Tiina Paunio, MD, PhD1,3,4
1Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland; 2Department of Physiology, University of Helsinki, Helsinki, Finland; 3Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland; 4Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland; 5Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Finland; 6Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland; 7Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
Sleeping 7 to 8 hours per night appears to be optimal, since both shorter and longer sleep times are related to increased morbidity and mortality. Depressive disorder is almost invariably accompanied by disturbed sleep, leading to decreased sleep duration, and disturbed sleep may be a precipitating factor in the initiation of depressive illness. Here, we examined whether, in healthy individuals, sleep duration is associated with genes that we earlier found to be associated with depressive disorder.
Population-based molecular genetic study.
Regression analysis of 23 risk variants for depressive disorder from 12 genes to sleep duration in healthy individuals.
Three thousand, one hundred, forty-seven individuals (25–75 y) from population-based Health 2000 and FINRISK 2007 samples.
Measurements and Results:
We found a significant association of rs687577 from GRIA3 on the X-chromosome with sleep duration in women (permutation-based corrected empirical P = 0.00001, β = 0.27; Bonferroni corrected P = 0.0052; f = 0.11). The frequency of C/C genotype previously found to increase risk for depression in women was highest among those who slept for 8 hours or less in all age groups younger than 70 years. Its frequency decreased with the lengthening of sleep duration, and those who slept for 9 to 10 hours showed a higher frequency of C/A or A/A genotypes, when compared with the midrange sleepers (7-8 hours) (permutation-based corrected empirical P = 0.0003, OR = 1.81).
The GRIA3 polymorphism that was previously found to be associated with depressive disorder in women showed an association with sleep duration in healthy women. Mood disorders and short sleep may share a common genetic background and biologic mechanisms that involve glutamatergic neurotransmission.
Utge S; Kronholm E; Partonen T; Soronen P; Ollila HM; Loukola A; Perola M; Salomaa V; Porkka-Heiskanen T; Paunio T. Shared genetic background for regulation of mood and sleep: association of GRIA3 with sleep duration in healthy Finnish women. SLEEP 2011;34(10):1309-1316.