PROPOFOL ANESTHESIA AND SLEEP
Propofol Anesthesia and Sleep: A High-Density EEG Study
Michael Murphy, PhD1,2; Marie-Aurelie Bruno, BSc3; Brady A. Riedner, BS1,2,4; Pierre Boveroux, MD3; Quentin Noirhomme, Ir, PhD3; Eric C. Landsness, PhD1,2,5; Jean-Francois Brichant, MD, PhD6; Christophe Phillips, Ir, PhD3; Marcello Massimini, MD, PhD7; Steven Laureys, MD, PhD3; Giulio Tononi, MD, PhD1; Melanie Boly, MD, PhD3
1Department of Psychiatry, Madison, WI; 2Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI; 3Coma Science Group, Cyclotron Research Centre and Neurology department University of Liege, Liege, Belgium; 4Clinical Neuroengineering Training Program, Madison, WI; 5Medical Scientist Training Program, University of Wisconsin-Madison, Madison, WI; 6Department of Anesthesiology, University Hospital of Liege, Liege, Belgium; 7Department of Clinical Sciences, Luigi Sacco, University of Milan, Milan, Italy
The electrophysiological correlates of anesthetic sedation remain poorly understood. We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia and compare them to sleep.
256-channel EEG recordings in humans during propofol anesthesia.
Hospital operating room.
Patients or Participants:
8 healthy subjects (4 males)
Measurements and Results:
Initially, propofol induced increases in EEG power from 12–25 Hz. Loss of consciousness (LOC) was accompanied by the appearance of EEG slow waves that resembled the slow waves of NREM sleep. We compared slow waves in propofol to slow waves recorded during natural sleep and found that both populations of waves share similar cortical origins and preferentially propagate along the mesial components of the default network. However, propofol slow waves were spatially blurred compared to sleep slow waves and failed to effectively entrain spindle activity. Propofol also caused an increase in gamma (25–40 Hz) power that persisted throughout LOC. Source modeling analysis showed that this increase in gamma power originated from the anterior and posterior cingulate cortices. During LOC, we found increased gamma functional connectivity between these regions compared to the wakefulness.
Propofol anesthesia is a sleep-like state and slow waves are associated with diminished consciousness even in the presence of high gamma activity.
Murphy M; Bruno MA; Riedner BA; Boveroux P; Noirhomme Q; Landsness EC; Brichant JF; Phillips C; Massimini M; Laureys S; Tononi G; Boly M. Propofol anesthesia and sleep: a high-density EEG study. SLEEP 2011;34(3):283-291.