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VOLUME 33, ISSUE 02

BRAIN GRAY MATTER CONCENTRATIONS IN OSA
Reduced Brain Gray Matter Concentration in Patients With Obstructive Sleep Apnea Syndrome

Eun Yeon Joo, MD, PhD1; Woo Suk Tae, PhD2; Min Joo Lee, MS1; Jung Woo Kang, MD1; Hwan Seok Park, MD1; Jun Young Lee, MD1; Minah Suh, PhD3; Seung Bong Hong MD, PhD1

1Sleep Center, Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; 2Neuroscience Research Institute, Kangwon National University College of Medicine, Chunchon City, Korea; 3Department of Biological Science, Sungkyunkwan University, Suwon, Korea



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Study Objectives: To investigate differences in brain gray matter concentrations or volumes in patients with obstructive sleep apnea syndrome (OSA) and healthy volunteers.
Designs: Optimized voxel-based morphometry, an automated processing technique for MRI, was used to characterize structural differences in gray matter in newly diagnosed male patients.
Setting: University hospital
Patients and Participants: The study consisted of 36 male OSA and 31 non-apneic male healthy volunteers matched for age (mean age, 44.8 years).
Interventions: Using the t-test, gray matter differences were identified. The statistical significance level was set to a false discovery rate P < 0.05 with an extent threshold of kE > 200 voxels.
Measurements and Results: The mean apnea-hypopnea index (AHI) of patients was 52.5/ h. On visual inspection of MRI, no structural abnormalities were observed. Compared to healthy volunteers, the gray matter concentrations of OSA patients were significantly decreased in the left gyrus rectus, bilateral superior frontal gyri, left precentral gyrus, bilateral frontomarginal gyri, bilateral anterior cingulate gyri, right insular gyrus, bilateral caudate nuclei, bilateral thalami, bilateral amygdalo-hippocampi, bilateral inferior temporal gyri, and bilateral quadrangular and biventer lobules in the cerebellum (false discovery rate P < 0.05). Gray matter volume was not different between OSA patients and healthy volunteers.
Conclusions: The brain gray matter deficits may suggest that memory impairment, affective and cardiovascular disturbances, executive dysfunctions, and dysregulation of autonomic and respiratory control frequently found in OSA patients might be related to morphological differences in the brain gray matter areas.
Keywords: Obstructive sleep apnea, Brain, Gray matter concentration, MRI, Voxel based morphometry

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